InSphero
InSphero life science company head quartered in Switzerland.
What is the 3D InSight™ Gastrointestinal Organoid model based on?
“The 3D InSight™ Gastrointestinal Organoid model is based on patient-derived human small intestine tissue. The model originates from ethically sourced biopsies and is expanded as long-term organoid cultures. In addition to the small intestine model, our biobank includes organoids derived from colon, rectum, and stomach tissue. These additional GI segment models are currently available for custom projects.”
View in the company profileWhat intestinal cell types are present in the 3D InSight™ Small Intestine Organoid model?
“3D InSightTM Small Intestine Organoid model represents a physiologically relevant “mini-gut” and contains the key epithelial cell types found in native intestinal tissue. These include enterocytes, goblet cells, Paneth cells, and enteroendocrine cells. The presence of these cell populations is confirmed through gene expression analysis and immunostaining.”
View in the company profileHow are organoids cultured in Gri3D® plates? How long?
“Organoids formation on Gri3D plates is driven by the sedimentation of uniformly distributed single cells into hydrogel microcavities without solid ECM. There cells aggregate and form organoids within each microwell with a dilute matrix cue that triggers polarization.”
View in the company profileIs the 3D InSight™ Gastrointestinal Organoid model proliferative or differentiated?
“The 3D InSight™ Small Intestine Organoid Model contains a mix population of both proliferative stem-cell and differentiated intestinal cell types. This balance enables physiologically relevant responses while maintaining proliferative capacity of the organoid.”
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