Glyphic Biotechnologies
Glyphic Biotechnologies: “Glyphic Biotechnologies is decoding the human proteome with ProSE™ (Protein Sequencing by Expansion), a single-molecule, high-throughput protein sequencing platform that reads all 20 amino acids and post-translational modifications de novo. Its goal is to accelerate the development of novel therapeutics and diagnostics and deepen our understanding of biology.”
What is protein sequencing?
“Protein sequencing is the process of determining the order of amino acids that make up a protein. Reading proteins directly, rather than inferring them from genes, reveals how biology actually functions, including modifications that genes alone can't predict.”
View in the company profileWhat is Protein Sequencing by Expansion (ProSE™)?
“ProSE™ is Glyphic's single-molecule, massively parallel protein sequencing platform. Peptides are functionalized with an initiating linker, then each amino acid is sequentially expanded and uniformly spaced in its original order, enabling the protein to be read one molecule at a time.”
View in the company profileHow is ProSE different from traditional methods like mass spectrometry?
“Traditional approaches have built-in blind spots: antibody-based methods like ELISA only detect proteins you already have a reagent for, and mass spectrometry typically matches signals against databases of known proteins. Both are biased toward what's already been characterized.”
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